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- THC strains are the most common. They produce the euphoric high associated with cannabis. While some find THC’s intoxicating effects to be relaxing, others may be sensitive to them and find that they actually worsen anxiety.
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When browsing cannabis strains or purchasing cannabis at a dispensary, you may notice strains are commonly broken up into three distinct groups: indica, sativa, and hybrid. Most consumers have used two of these three cannabis types (indica and sativa) as a standard for predicting effects.
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Synthetic cannabinoids are a class of molecules that bind to the same receptors to which cannabinoids (THC and CBD) in cannabis plants attach. They are designer drugs, commonly sprayed onto plant matter and are usually smoked, although they have also been ingested as a concentrated liquid form in the US and UK since 2016. They have been marketed as herbal incense, or “herbal smoking blends”, and sold under common names like K2, spice, and synthetic marijuana. They are often labeled “not for human consumption” for liability defense. A large and complex variety of synthetic cannabinoids are designed in an attempt to avoid legal restrictions on cannabis, making synthetic cannabinoids designer drugs.
Most synthetic cannabinoids are agonists of the cannabinoid receptors. They have been designed to be similar to THC, the natural cannabinoid with the strongest binding affinity to the CB1 receptor, which is linked to the psychoactive effects or “high” of marijuana. These synthetic analogs often have greater binding affinity and greater potency to the CB1 receptors. There are several synthetic cannabinoid families (e.g.AM-xxx, CP-xx,xxx, HU-xx, JWH-xxx) classified based on the base structure.
Synthetic marijuana compounds began to be manufactured and sold in the early 2000s. From 2008 to 2014, 142 synthetic cannabinoids were reported to the European Monitoring Centre for Drugs and Drug Addiction (EMCDDA).
Reported user negative effects include palpitations, paranoia, intense anxiety, nausea, vomiting, confusion, poor coordination, and seizures. There have also been reports of a strong compulsion to re-dose, withdrawal symptoms, and persistent cravings. There have been several deaths linked to synthetic cannabinoids. The Centers for Disease Control and Prevention (CDC) found that the number of deaths from synthetic cannabinoid use tripled between 2014 and 2015. In 2018, the United States Food and Drug Administration warned of significant health risks from synthetic cannabinoid products that contain the rat poison brodifacoum, which is added because it is thought to extend the duration of the drugs’ effects. Severe illnesses and death have resulted from this contamination.
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